From Immortal Life:

The phenomenon known as aging is a result of pathological changes that are somewhat controllable using existing technologies. By prolonging our healthy lifespans today (by protecting against these known mechanisms of aging), we put ourselves in a position to take advantage of future medical breakthroughs that could result in dramatic extensions of the human lifespan.

This essay is an excerpt from David’s book: Smart, Strong and Sexy at 100 .

Here are some of the underlying controllable culprits involved in pathological aging and what humans can do right now to help counteract them:

1. Chronic Inflammation 

Aging people suffer an epidemic of outward inflammatory diseases such as arthritis, but chronic systemic inflammation also damages brain cells, arterial walls, heart valves, and other structures in the body. Heart attack, stroke, heart valve failure and Alzheimer’s senility have been linked to the chronic inflammatory cascade so often seen in aging humans.

Some methods to counteract: Eat a low-glycemic diet rich in omega-3 and monounsaturated fats, but low in omega-6 and saturated fats (such as salmon, other fatty fish and fish oil; avocados; seeds and nuts; extra virgin olive oil and fresh produce. Take supplements that provide omega-3 fatty acids, curcumin, garlic, ginger, pomegranate, luteolin, lipoic acid, 5-Loxin, vitamin K, and vitamin E. Avoid eating foods cooked at high temperatures, and minimize foods high in arachidonic acid such as eggs and dairy and the fat in red and white meat. Have your blood tested for C-reactive protein. If C-reactive protein is chronically elevated, request an Inflammatory Cytokine blood test panel.

2. Glycation 

It is well-known that diabetics age prematurely, but even non-diabetics suffer from a devastating chemical reaction called glycation, where protein or fat molecules bind to glucose molecules in the body to form non-functioning structures. Glycation is most evident in senile dementia, stiffening of the arterial system, and degenerative diseases of the eye.

Some methods to counteract: Take 1000 mg a day of carnosine, 50–150 mg a day of benfotiamine, lots of antioxidants, and avoid eating foods cooked at high temperatures.

3. Methylation Deficit

Cellular DNA requires constant enzymatic actions (methylation) for maintenance and repair. Aging cripples youthful methylation metabolism causing DNA damage that can manifest as cancer, liver damage, and brain cell degeneration.

Some methods to counteract: Consume at least 800 mcg a day of folic acid, 300 mcg a day of vitamin B12, 50 mg a day of vitamin B2, 100 mg a day of vitamin B6, 500–3000 mg a day of TMG.

Elevated homocysteine is a red flag that warns you that your body is not methylating properly. Elevated homocysteine is the strongest modifiable predictor of overall mortality. If homocysteine levels remain persistently high, take 800–5000 mcg of 5-methylfolate twice a day.

4. Mitochondrial Energy Depletion 

The cell’s energy powerhouses (the mitochondria) require a complex series of chemicals to be present in order to maintain critical functions such as transporting nutrients through the cell membrane and purging the cell of toxic debris. Mitochondrial energy depletion can result in congestive heart failure, muscle weakness, fatigue and neurological disease.

Some methods to counteract: Consume 20 mg of PQQ daily, 1500-3000 mg a day of carnitine in the forms of acetyl-l-carnitine, acetyl-l-carnitine arginate, propionyl-l-carnitine, 150–300 mg a day of R-lipoic acid, 100–300 mg of coenzyme Q10. Consider calorie restriction.

5. Hormone Imbalance 

The trillions of cells in the human body are delicately synchronized to function by chemical signals called hormones. Aging creates a severe hormone imbalance that is often a contributing cause to many diseases associated with aging including depression, osteoporosis, coronary artery disease, and loss of libido.

Some methods to counteract: Have your blood checked for the following.

  1. DHEA -S
  2. Pregnenolone
  3. Total and Free testosterone
  4. Estradiol (males)
  5. Total Estrogen (females)
  6. Progesterone (females and males)
  7. Thyroid Panel

Restore deficient hormones to youthful ranges and reduce excess hormones to safe ranges. Retest blood in sixty days to fine-tune dosing. Refer to Male and Female Hormone Modulation protocols and DHEA Restoration Therapy by logging in to www.lef.org/maxlife.202

6. Calcification 

Calcium ions are transported into and out of cells through calcium channels in the cell membrane. Aging disrupts calcium transport, and the result is excess calcium infiltration into cells of the brain, heart valves and middle arterial wall (causing arteriosclerosis).

Some methods to counteract: Take around 10 mg of a vitamin K supplement that provides both vitamin K1 and K2, and drink 8-ounces of pomegranate juice or its powdered equivalent. Follow a lifestyle that protects against atherosclerosis and endothelial dysfunction. Have standard blood chemistry tests done annually to rule out excess blood calcium levels (hypercalcemia). You can get qualified affordable blood testing from Life Extension Foundation. www.lef.org/maxlife.

7. Fatty Acid Imbalance 

The body requires essential fatty acids to maintain cell energy output. Aging causes alterations in enzymes required to convert dietary fats into the specific essential fatty acids the body requires to sustain life. The effects of a fatty acid imbalance may manifest as an irregular heart beat, joint degeneration, low energy, hyper-coagulation, dry skin, or a host of other common ailments associated with normal aging.

Some methods to counteract: Make sure to consume enough omega-3 fatty acids and avoid excess consumption of omega-6 fats. Make sure monounsaturated fats (such as extra virgin olive oil) are part of your regular diet.

8. DNA Gene Mutation 

Numerous synthetic and natural compounds mutate cellular DNA and cause cancer cells to form. Aging cells lose their DNA gene repair mechanisms and the result is that DNA genetic damage can cause cells to proliferate out of control: i.e., turn into cancer cells.

Some methods to counteract: Restrict calorie intake, but do so without inducing malnutrition. Supplement with 20 mg a day of resveratrol and/or 500–1700 milligrams a day of the drug metformin (under physician supervision.) Include lots of antioxidants in your supplement program. Limit amounts of deep-fried foods and those cooked at high temperatures. Take 100 mg of chlorophyllin with most meals.

9. Immune Dysfunction 

Only if your immune system is depressed will it normally allow a virus to take hold. So maybe a depressed immune dysfunction is the disease. In fact, maybe aging is the disease that depresses the immune system.

For a variety of reasons, the aging immune system loses its ability to attack bacteria, viruses, and cancer cells. In aging humans, excessive levels of dangerous cytokines are produced that cause the immune system to turn on its host and create autoimmune diseases associated with aging such as rheumatoid syndrome.

Some methods to counteract: Maintain youthful hormone balance and guard against excess free radical production. Consider supplementing daily with 100 mg of Beta-1, 3-D Glucan Complex to boost certain immune parameters while taking 8–16 mg daily of 203 to access the latest Immune System Strengthening Protocol. 204

blood tests to guard against arterial wall damaging factors such as excess C-reactive protein, fibrinogen, LDL, homocysteine, insulin, glucose, triglycerides. Take steps to increase HDL and free testosterone if blood tests reveal levels that are too low.

10. Non-Digestive Enzyme Imbalance 

Internal cellular functions depend on multiple enzymatic reactions occurring with precise timing. Aging causes enzyme imbalances primarily in the brain and liver, which results in severe neurological diseases such as Parkinson’s or the persistent memory loss aging people so often complain about. Impaired liver function results in toxic damage to every cell in the body. No supplements, oral or injected, no hormones, or anything else help when your liver is weak. One of the best ways to maintain optimal liver function is to boost your cells’ glutathione levels.

Some methods to counteract: Consider supplementing with 400–1200 mg a day of SAMe (s-adenosyl-methionine) and 900 mg a day of silymarin.

11. Digestive Enzyme Deficit 

The aging pancreas often fails to secrete enough digestive enzymes, while the aging liver does not secrete enough bile acids. The result is the chronic indigestion people complain about as they age.

Some methods to counteract: Take a standardized digestive enzyme supplement before meals. If problems persist, take a supplement that provides artichoke or black radish extracts to promote bile secretion from liver to facilitate digestion of fats. Note: to maintain a healthy gut, take probiotics regularly as well as fermented foods such as tofu, homemade yogurt, tempeh, miso and vinegar. You can find probiotics at most health food stores.

12. Excitotoxicity 

The aging brain loses control of its release of neurotransmitters such as glutamate and dopamine, resulting in devastating brain cell damage and destruction.

Some methods to counteract: Take 1–40 mg a day of sublingual methylcobalamin and 20 mg a day of vinpocetine. Parkinson’s patients should take 200–300 mg of the ubiquinol or water soluble ubiquinone form of CoQ10.

13. Circulatory Deficit 

Microcapillary perfusion of blood to the brain, eye, and skin is impaired as a part of normal aging. The result is that disorders of the eye (such as cataract, macular degeneration, and glaucoma) are the number one aging-related degenerative disease. Major and mini-strokes are common problems associated with circulatory deficit to the brain. The skin of all aged people shows the effects of lack of nutrient-rich blood to the upper layers.

Some methods to counteract: Consume lots of flavonoids found in ginkgo, blueberry, matcha green tea, pomegranate, and grape seed extracts. Further maintain healthy endothelial function by supplementing with omega-3 fatty acids. Utilize comprehensive 204

blood tests to guard against arterial wall damaging factors such as excess C-reactive protein, fibrinogen, LDL, homocysteine, insulin, glucose, triglycerides. Take steps to increase HDL and free testosterone if blood tests reveal levels that are too low.

14. Oxidative stress 

Free radicals are unstable molecules that have been implicated in most diseases associated with aging. Antioxidants have become popular supplements to protect against free radical-induced cell damage, but few people take the proper combination of antioxidant supplements to adequately compensate for age-induced loss of endogenous antioxidants such as SOD and catalase.

Some methods we use to counteract: Take protected glutathione, SOD and catalase-boosting nutrients, avoid diet and lifestyles that promote oxidative stress, consume lots of antioxidant foods and supplements such as gamma tocopherol and pomegranate.

Notice that oxidative stress is listed as number fourteen on the above list of controllable factors that cause aging-related diseases. While suppressing the free radicals that cause oxidative stress protects against many disorders, there is clearly much more that can be done to stave off aging than merely taking antioxidant supplements.

Children can benefit by taking vitamin supplements, but it is the aging human whose body is depleted of the endogenous antioxidants, hormones, enzymatic repair systems, and other biological chemicals needed to sustain life. What is optional in childhood becomes mandatory as humans enter middle-age and become vulnerable to the plethora of degenerative diseases that await them if they do not adequately protect themselves

Rhis essay is an excerpt from David’s book: Smart, Strong and Sexy at 100.

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The body’s “fountain of youth” could be in the hypothalamus, an important part of the brain for emotional regulation:

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12143.html

For the role the hypothalamus plays in emotions see here: http://www.preservearticles.com/201104185522/role-of-hypothalamus-in-emotion.html

 

Part of my graduate work was tying together the soft science of yoga with the hard science of neuro-endocrinology. My thesis was that breathwork could result in stimulating the various endocrine glands to secrete the necessary hormones for re-starting brain growth in regions like the hypothalamus and amygdala, which are responsible for emotion. Additionally, as many people, including Leonard Orr and Jim Leonard postulated, emotional integration helps one live longer, theorizing correctly that negative emotions (and the related stress hormones like cortisol) are what actually kill us.

In the yogic tradition the location of the hypothalamus coincides with what is known as bindu visarga. From that point emanates amrita, which is roughly translated as the nectar of immortality. It is considered that it flows downward from that point and gets consumed by the digestive system. Certain techniques, usually involving inverted body position, reverse the flow of amrita, which can than get assimilated by the body.

Myron Stoloroff also talked about the deep connection between emotional healing and a life of vitality in his book Thanatos to Eros.

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From Yale News:

The flip of a single molecular switch helps create the mature neuronal connections that allow the brain to bridge the gap between adolescent impressionability and adult stability. Now Yale School of Medicine researchers have reversed the process, recreating a youthful brain that facilitated both learning and healing in the adult mouse.

Scientists have long known that the young and old brains are very different. Adolescent brains are more malleable or plastic, which allows them to learn languages more quickly than adults and speeds recovery from brain injuries. The comparative rigidity of the adult brain results in part from the function of a single gene that slows the rapid change in synaptic connections between neurons.

By monitoring the synapses in living mice over weeks and months, Yale researchers have identified the key genetic switch for brain maturation a study released March 6 in the journal Neuron. The Nogo Receptor 1 gene is required to suppress high levels of plasticity in the adolescent brain and create the relatively quiescent levels of plasticity in adulthood.  In mice without this gene, juvenile levels of brain plasticity persist throughout adulthood. When researchers blocked the function of this gene in old mice, they reset the old brain to adolescent levels of plasticity.

“These are the molecules the brain needs for the transition from adolescence to adulthood,” said Dr. Stephen Strittmatter. Vincent Coates Professor of Neurology, Professor of Neurobiology and senior author of the paper. “It suggests we can turn back the clock in the adult brain and recover from trauma the way kids recover.”

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Chronic Buckyball Ingestion Doubles Lifespan in Rats

April 26th, 2012 | Posted by paul in Uncategorized - (Comments Off on Chronic Buckyball Ingestion Doubles Lifespan in Rats)

Another way of saying this is that C60 slows down aging by half (at least in rats). Can this translate to humans? If it works and you start when you’re 45, and normally have another another 35 years to live, it would double that to 70 years, getting you at least to 115.

From Extreme Longevity:

C(60) fullerene is a naturally occurring molecule containing 60 carbon atoms arranged in a sphere. It is famously known as the buckyball, short for buckminsterfullerene, and discovered in 1985.

Since 1993, the molecule has been suspected to have multiple potential biological benefits. This list includes UV and radioprotection, antiviral, antioxidant, and anti-amyloid activities, allergic response and angiogenesis inhibitions, immune stimulating and antitumour effects, enhancing effect on neurite outgrowth, gene delivery, and even hair-growing activity.

In the current study researchers fed the molecule dissolved in olive oil to rats and compared outcomes to a control group of rats who got plain olive oil.

The main question they wanted to answer was whether chronic C60 administration had any toxicity, what they discovered actually surprised them.

“Here we show that oral administration of C60 dissolved in olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight) to rats not only does not entail chronic toxicity,” they write “but it almost doubles their lifespan.”

“The estimated median lifespan (EML) for the C60-treated rats was 42 months while the EMLs for control rats and olive oil-treated rats were 22 and 26 months, respectively,” they write.

Using a toxicity model the researchers demonstrated that the effect on lifespan seems to be mediated by “attenuation of age-associated increases in oxidative stress”

They also demonstrated that the compound is fully absorbed via the GI tract and totally eliminated from the body in 10 hours.

“These results of importance in the fields of medicine and toxicology should open the way for the many possible -and waited for- biomedical applications of C60 including cancer therapy, neurodegenerative
disorders, and ageing,” they conclude.

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From New Scientist:

The key gene that keeps embryonic stem cells in a state of youthful immortality has been discovered.

The breakthrough may one day contribute to turning ordinary adult cells into those with the properties of human ESCs. This would end the need to destroy embryos to harvest the cells for new medical treatments.

ESCs are unique as they are “pluripotent” – capable of differentiating into the different cells in the body – and hold great potential for treating damaged or diseased organs. But until now scientists did not know how a stem cell renews itself or develops into an new kind of cell.

The gene found in mouse ESCs and some human equivalents appears to be the “master gene”, coordinating other genes to allow stem cells to multiply limitlessly while still retaining their ability to differentiate. It has been christened Nanog after the land in Celtic myth called Tir nan Og, whose inhabitants remain forever young.

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Living to 1000 and Beyond

February 28th, 2003 | Posted by paul in Uncategorized - (Comments Off on Living to 1000 and Beyond)

Ask yourself this question – if you could live indefinitely in perfect health with endless opportunities for happiness and prosperity would you? If not, why not? My personal take is I’m going to live forever or die trying. When I first became an immortalist around the age of 12, most people including my parents thought I was being silly or fanciful. They never once asked me how I thought such a thing was possible let alone likely if I played my cards right. The basic argument was first explained to my knowledge in 1978 by Robert Anton Wilson in his article Next Stop: Immortality.

Assuming you are in your 40’s or younger now, you can expect to live at least another 30 to 40 years without any further advances in medical technology. That means you will still be around in 2030. But think about all of the medical advances happening now and will become practical in the next 10 years – adult stem cell organ regeneration, genetic therapy, cures for diabetes, alzhiemers and parkinsons, and possibly even several forms of cancer. By 2020, we are likely to see dramatic advances in nanomedicine, where nanomachines in our bodies will clean arteries, repair cellular and genetic damage and possibly repair/regenerate the telomerase. So by 2020, a combination of advanced genetic therapies, organ and cellular regeneration, lifespans could easily be extended by an additional 40 years, bringing us to 2070. But we are still hanging out in 2020. Between 2020 and 2040, and assuming we don’t destroy ourselves in the process, nanotechnology will likely reach full maturity. With fully mature nanomachines our bodies and any damage that would occur from aging or disease could be repaired and even reversed. This means that if you look and feel like a 70 year old in 2030, by 2040 you will look and feel like a 25 year old again. No more aging. This is no joke, as wear and tear on our bodies is just collective damage at the molecular level, now repairable by nano-enabled molecular repair machines. End result by 2040 – indefinite lifespans.

So if you play your cards right, eat, exercise and take care of yourself you will live to see an accelerated return on longevity, where the increase in average lifespan increases faster than we age. So, are you ready and willing to live indefinitely? Now that you could live to see your 1000th birthday, what are you going to do with your life?

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